Determination of Syringe Penetration Angles in Pharmaceutical Vials.

Beckert, J. (2013) Determination of Syringe Penetration Angles in Pharmaceutical Vials.. 42nd Annual MAFS meeting (Trace Evidence section) (Dayton, OH).

Presented on: 10/3/2013

The identification of contaminant particles in pharmaceutical vials is a task befitting well-trained chemical microscopists. It generally involves the careful isolation of microscopic material and the subsequent analysis by one or more applicable analytical techniques. Polarized light microscopy is typically the first method employed, and the information obtained here determines subsequent steps (if required): often chemical (e.g., FTIR and/or Raman) or elemental (e.g., SEM-EDS) analyses. A thorough analysis may be able to suggest, or in some circumstances, prove the origin of the contaminant particle(s). Occasionally, additional information is requested from the examining scientist.

This talk will first briefly discuss a case in which the contaminant particles from several pharmaceutical samples were shown to originate from the rubber stoppers used to cap the vials. However, the majority of this presentation will focus on the methodology used to estimate the syringe penetration angles through the rubber stoppers and additional experimentation conducted to evaluate the accuracy of these estimates.

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